Heart Attack OverviewIf you are having pain or discomfort in your chest, jaw, shoulder, arm, or back and think you may be having a heart attack.
If you think you are having a heart attack, seek help immediately. Do not ignore chest pain or discomfort. Time is of vital importance. Go immediately to a hospital emergency department. Do not attempt to drive yourself or have someone else drive you. Call 911 for emergency transport.
The heart is a muscular pump located in the chest. Its job is to pump blood around the body via the circulatory system of blood vessels. The heart consists of 4 chambers: right atrium and right ventricle, and left atrium and left ventricle.
Blood is depleted of oxygen after circulating through the body. This blood returns into the right atrium. From there the blood flows into the right ventricle, which pumps the blood out to the lungs for oxygenation.
The oxygen-rich blood then returns to the left atrium. From there it flows into the left ventricle and is pumped out at high pressure into the arteries.
The high pressure is generated by powerful contraction of the heart muscle.
This raises the pressure of the blood and enables it to flow through the extensive network of arteries to every part of the body and return to the heart.
For this pumping action, the heart has to be strong.
The heart is nourished by the blood supplied directly to the heart muscle through the coronary arteries.
The strength of the heart muscle depends very much on this blood supply.
The coronary arteries are usually strong, elastic, and quite flexible. The inner lining of the arteries is normally smooth. This allows the blood to flow smoothly without clotting.
Heart attack is caused by sudden loss of blood and oxygen to your heart.
The most common condition that predisposes a person to heart attack is coronary heart disease, or coronary artery disease, due to atherosclerosis, or fatty build up of plaque on the inner lining of coronary arteries.
The plaque and resulting blood clots block the artery partially or completely, reducing the amount of blood that can flow through the artery to the heart.
This cuts off the oxygen supply to part of the heart muscle.
If the blood supply is cut off long enough, that part of the heart muscle dies. This is a heart attack.
If a large enough part of the heart muscle is affected, a dangerous rhythm disorder called ventricular fibrillation may occur.
If this happens, the heart may stop. This is called cardiac arrest, and most people who have cardiac arrest die.
Despite immense medical progress in the last 3 decades, heart disease continues to be a major health problem in both industrialized and developing nations.
About 1.5 million Americans suffer a heart attack each year (that’s 1 heart attack every 20 seconds).
Many people die before getting medical attention. Approximately 90-95% of people who reach a hospital alive after a heart attack will survive.
Overall, about one third of people who have a heart attack die.
Heart disease is the leading cause of death in the United States.
Clearly, time is of the essence. Recognizing the symptoms of a heart attack and seeking immediate medical attention may mean the difference between life and death.
Immediate death may be avoided if cardiopulmonary resuscitation (CPR) is begun within 4 minutes of the cardiac arrest.
CPR involves breathing for the person (mouth-to-mouth resuscitation) and performing chest compressions to keep the blood circulating. This provides at least a small amount of oxygen to the heart and brain.
Survival depends on quick action.
Emergency personnel will assess the situation quickly. They may record an electrocardiogram (ECG).
If the person has ventricular fibrillation or there is no pulse, they may administer electrical current to the chest (defibrillation) to "shock" the heart back to normal rhythm.
Other emergency treatments include medications and CPR.
Bystanders can help a cardiac arrest victim before emergency personnel arrive.
Ventricular fibrillation often can be treated successfully with a defibrillator.
Automated external defibrillators (AEDs) are now becoming available in many public places such as airports and airplanes, shopping malls, sports arenas, and office buildings.
These devices are designed so that they can be used in cardiac arrest by untrained bystanders.
Even if an AED is not available, you can take part in the "chain of survival" by performing CPR until help arrives.
Heart Attack CausesWith advancing age, cholesterol and calcium are deposited gradually in the walls of the coronary arteries. These deposits are called plaques. The process is known as atherosclerosis, or "hardening of the arteries."
A diet high in cholesterol combined with smoking and lack of exercise can accelerate this process.
As these plaques grow, they begin to impede the flow of blood.
The growing plaque is like a firm shell with a soft inner core containing cholesterol.
As blood hits a plaque during each heartbeat, the plaque may crack open and expose the inner cholesterol.
The cholesterol may cause a blood clot to begin to form.
The plaque and the blood clot block the artery partially or completely. The more the artery is blocked, the greater the resulting damage to the heart.
Atherosclerotic coronary artery disease
This most common type of heart disease is associated with several risk factors. The greater the number of risk factors you have, the more likely you are to have atherosclerosis. The most common risk factors are as follows:
Hereditary (runs in the family)
High cholesterol in blood, especially high levels of "bad cholesterol" (LDL, low-density lipoprotein) and low levels of "good cholesterol" (HDL, high-density lipoprotein)
Cigarette smoking or other tobacco use, including cigars and chewing tobacco
Obesity or excess weight
High blood pressure (hypertension)
Diabetes
Physical inactivity, lack of regular exercise (sedentary lifestyle)
High-fat diet
Emotional stress
Type-A personality (hard-driving, perfectionist)
Nonatherosclerotic coronary artery disease
Coronary arteries can be blocked by conditions other than atherosclerosis. These include inflammatory diseases of the arteries, trauma such as a cut or stab wound to the heart, and diseases that cause thickening of the coronary arteries.
Coronary embolization may cause a heart attack. Coronary embolization refers to a clot from elsewhere in the body breaking off and traveling to the heart.
Other causes of heart attack are blood or oxygen supply problems or outside influences such as cocaine abuse and complications from bypass or catheterization.
Certain heart problems leading to heart attack may be present from birth.
Heart Attack SymptomsChest pressure, discomfort, or a bandlike sensation around the chest with squeezing or heaviness is a common symptom of heart attack.
About one fourth of people having a heart attack have no pain ("silent" heart attack).
Silent heart attacks are more frequent in people with diabetes.
The following symptoms suggest a heart attack:
Chest pain or pressure (heaviness)
Jaw pain, or extension of pain into the arms or shoulder, especially the left arm
Unexplained shortness of breath
Unexplained sweating
Heartburn or feeling of indigestion
Nausea or vomiting
Back pain or upper abdominal pain
General lethargy or listlessness (malaise)
When to Seek Medical CareCall your health care provider if you have these symptoms, which are warning signs of a heart attack.
Chest pain or pressure or feeling of indigestion on exertion
Shoulder or arm pain, left or right or both, during physical or stressful activity
Jaw pain
Unexplained shortness of breath (while at rest or comes on suddenly)
Unexplained nausea, vomiting, or sweating
Fainting spell
Palpitations (awareness of rapid or pounding heartbeat)
Dizziness
If these symptoms do not go away in 5 minutes, call 911 immediately for emergency medical transport to a hospital. Do not try to drive yourself.
Each year, thousands of Americans die because they did not seek medical attention in time.
It is good to be cautious and go to the hospital.
This may mean the difference between life and death.
Don't worry about "wasting everyone's time." You aren't.
If you are not having a heart attack, that's fine. You may be able to receive treatment for whatever is causing your symptoms.
Exams and TestsA heart attack is not a quick event that lasts a few minutes and is over.
A heart attack is a process that continues over several hours.
Every minute that passes before treatment is begun, your heart sustains more damage.
You must seek medical attention as soon as you suspect you are having a heart attack.
If you arrive at the hospital in an ambulance, the staff will be ready for you.
They will evaluate your condition rapidly by examining you and, if you can answer, asking you questions about your symptoms.
They will obtain an electrocardiogram (ECG) right away to look for signs of heart attack.
A quick diagnosis is essential for starting treatment as soon as possible.
If you are thought to be having a heart attack, you may undergo the following tests upon arrival and/or during the next few days of your hospital stay.
Blood tests: Routine blood tests include blood cell counts, chemistry and electrolytes, and coagulation (clotting) function.
Cardiac enzymes: When heart muscle is damaged, certain muscle proteins are released into the bloodstream and can be measured. Elevations of the levels of certain of these proteins, known as cardiac enzymes, strongly suggest that a heart attack is in progress or has occurred recently. Repeated testing of blood samples for cardiac enzymes is helpful in making the diagnosis of a heart attack, especially when the ECG is not diagnostic.
Other enzymes: Some other enzymes tested include AST (SGOT, aspartate transferase) and LDH (lactate dehydrogenase).
The 2 most measured enzymes are creatine kinase (CK) and troponin.
Creatine kinase is released from the cardiac muscle cells as they die and as their membranes dissolve. The level of this enzyme takes a number of hours after the beginning of the heart attack to peak. It returns to normal by 24 hours after the beginning of the heart attack. A form of this enzyme called MB subform is quite specific in showing cardiac damage.
Troponin-I and troponin-T are very useful enzyme tests. The levels of these enzymes rise by 6-8 hours after the heart attack begins and remain elevated above normal for as long as a week. To some extent, the level of troponin can predict the likelihood of complications for a person with a heart attack. The levels may also helpful in deciding what treatments should be used.
Electrocardiogram: This test detects the electrical activity of the heart and records graphlike tracings of each heartbeat (waves).
It is safe and painless, and it takes only a few minutes.
An ECG is performed by taping electrodes on your arms, legs, and chest. The electrodes pick up the electrical impulses of your heart from different points of view in your chest.
ECG abnormalities diagnostic of heart attack are sometimes seen early in a heart attack, but the ECG may be normal at first and need to be repeated.
Sometimes existing ECG abnormalities may make the diagnosis difficult.
Chest x-ray: This is not always done, but it can show abnormalities in the size or shape of the heart and indicate if fluid is collecting in the lungs, a sign or poor circulation.
Echocardiogram (echo): This is an ultrasound examination of the heart. The ultrasound device uses sound waves to create a detailed "picture" of the heart, which are then transmitted to a video monitor.
This is a safe, noninvasive, and very helpful test.
Echo may show problems in the heart structure, such as abnormalities in the movements of the heart wall. A heart attack is a damaged heart wall.
It can show abnormal enlargement or pouching of the heart wall (aneurysm).
Echo may also visualize complications of heart attack including valve problems, rupture of the heart muscle, or accumulation of fluid in the cardiac sac (pericardial effusion).
The most important information obtained from the echo is the ejection fraction. This is a measurement of the strength of heart muscle. This information may be used to help predict outcome and to decide on treatment.
Coronary angiography: This is the best test for identifying blockages in the coronary arteries.
It often is performed for people with persistent pain and those who have not received "clot-busting" drugs to re-open their blocked artery.
At some hospitals, people are taken directly into the catheterization, or cath, lab from the emergency department after initial evaluation.
In the cath lab, a long, thin plastic tube (catheter) is put into the femoral artery (in the groin) or the brachial or radial artery (in the arm) and guided into the openings of the coronary arteries. Dye is injected into the arteries to make them stand out on x-ray. Pictures are recorded for later review.
Coronary angiography is an invasive test with potentially serious complications, but when performed by an experienced doctor, the risk of complications is relatively small.
An angiogram is the best test to determine which treatment is most appropriate: medication, angioplasty, stent placement, or bypass surgery.
A stress test may be performed before a person leaves the hospital, after the patient is stable and recovering from the heart attack and/or procedure.
Exercise stress testing involves recording an ECG while the heart is stressed and again at rest.
The "stress" is usually exercise, namely, walking on a treadmill.
Speed and elevation are gradually increased while recording the ECG.
Certain changes in the ECG indicate possible coronary artery blockage.
The exercise stress test is about 60-70% accurate in predicting increased risk of future heart attacks.
If the stress test indicates fairly severe blockage, coronary angiography may be needed to confirm the diagnosis and determine the need for further treatment.
Radionuclide stress testing is another type of stress testing.
It uses a special camera that sees blood flow after a tiny dose of a radioactive "dye" (isotope) is injected into the blood.
It measures the quantities of blood flow that reach the different parts of the heart muscle through the coronary arteries.
Like the exercise stress test, pictures are obtained with exercise on the treadmill and then with rest.
People who are unable to walk on the treadmill may be given medication to "stress" the heart muscle.
If a particular coronary artery is blocked partially or completely, the part of the heart supplied with blood by that artery would appear as a "cold spot" on the pictures because no radioactive isotope reaches that area.
This test is quite accurate in diagnosing coronary artery blockage. The small amount of radioactivity is not considered to be harmful.
Heart Attack Treatment
Self-Care at HomeIf you think you are having a heart attack, seek help immediately. Do not ignore chest pain or discomfort. Time is of vital importance. Call 911 for emergency transport to the hospital. Do not try to drive yourself or being driven by someone else.
If you have regular-strength or baby aspirin available and you are not strongly allergic, chew and swallow 1 regular aspirin or a baby aspirin.
At this dose, aspirin may help maintain blood flow through a clot-filled artery by inhibiting blood clotting.
Chewing gets the aspirin into your system faster than swallowing it whole.
If you have had angina and been given nitroglycerin, take as recommended by your health care provider. Exact instructions will depend on the form of the nitroglycerin.
If you have had a heart attack before, or if you have several risk factors, the following steps may help prevent heart attacks and save you from severe disability or even death.
Take a low-dose aspirin tablet (160 or 325 mg) every day. Aspirin increases the risk of bleeding in some people. Ask your health care provider before taking daily aspirin.
If you smoke, quit. This is the single best lifestyle change you can make. After 3 years of not smoking, the risk of heart disease drops to the level of a nonsmoker. Your health care provider can help you quit smoking through behavioral changes, medications, or use of nicotine replacement products.
Lower the cholesterol level in your blood. Lowering your cholesterol, especially the level of "bad" LDL cholesterol, keeps plaques from building up in the coronary arteries. The total cholesterol level should be kept below 200 mg/dL, and the LDL cholesterol level below 130 mg/dL (under 100 mg/dL in those with known heart disease or diabetes). Some people are able to control their cholesterol level by changing what they eat, lose weight, and exercise more; others require medication.
Keep your intake of calories from fat under 30% of your total calories. This translates to an intake of less than 60 grams of fat per day for an adult. Most diets in Western countries contain more fat than is recommended.
Control blood pressure. Uncontrolled high blood pressure is one of the most common causes of heart disease.
Control diabetes carefully. Uncontrolled diabetes increases your risk of heart disease, heart attacks, and circulation problems.
If you take hormone replacement therapy (HRT), talk with your health care provider right away. HRT is no longer considered to protect women from heart disease and heart attacks.
Medical TreatmentMedical treatment may be started immediately, before a definite diagnosis of a heart problem is made.
General treatment measures include the following:
Oxygen through a tube in the nose or face mask
Nitroglycerin under the tongue
Pain medicines (morphine or meperidine)
Aspirin: Those with allergy to aspirin may be given clopidogrel (Plavix).
Clot-dissolving medicines: The tissue plasminogen activators (tPAs) can actually dissolve clots.
The earlier these drugs are given, the better the chance of dissolving the clot and opening the blocked artery, protecting the heart muscle from further injury.
If more than 12 hours has passed since the onset of chest pain, these drugs are less helpful.
Potential risks of this therapy include bleeding.
The most serious risk is a stroke (bleeding into the brain).
Angioplasty: Emergency coronary angiography and coronary balloon angioplasty (percutaneous transluminal coronary angioplasty, or PTCA) are available in hospitals equipped with a full-service cardiac catheterization laboratory. This is the most direct method of removing blockage in a coronary artery.
Coronary balloon angioplasty is an extension of coronary angiography.
A long, thin tube (catheter) is inserted in an artery in the groin or arm.
At the tip of the catheter is a tiny, elongated balloon, which is threaded over a hair-thin guidewire into the narrowed coronary artery.
Once the balloon is positioned at the blockage in the coronary artery, it is inflated.
The balloon pushes aside the plaque and clot that are blocking the artery, allowing blood to flow more freely.
The balloon is then deflated and removed with the catheter.
Stenting: A stent is a small, metal springlike device that may be inserted into a coronary artery after balloon angioplasty. After the catheter and balloon are removed, the stent stays in place, holding the artery open. A stent is better than angioplasty alone at keeping the artery from narrowing again.
Atherectomy: Sometimes the plaques are too rigid, bulky, or calcified to be treated by balloon angioplasty. In these cases, the plaque often can be removed by cutting it out with a drill-like rotary blade or a laser or other tool.
MedicationsIf you are having a heart attack, you will almost certainly be given some or all of these medications while you are in the hospital. Some you will continue taking at home.
Intravenous (IV) nitroglycerin has been shown to improve blood flow to the heart muscle by relaxing (dilating) the coronary arteries and increasing blood flow. It is usually given for 24-48 hours continuously.
Heparin is a "blood thinner," or anticoagulant, which may be given after a heart attack. Heparin does not remove an existing clot, but it reduces the tendency of blood to clot in the coronary arteries. Some newer forms of heparin have recently been introduced that can be given as a shot instead of through an IV line.
Beta-blockers are medications that decrease the heart rate and blood pressure. This reduces the heart's workload and thus the amount of oxygen it needs. Beta-blockers may help prevent heart irregularities/life threatening rhythm disorders and future heart attacks.
Angiotensin-converting enzyme (ACE) inhibitors may prevent repeat heart attacks and other problems when started early during a heart attack. They are especially useful in people with diabetes and those with a weakened heart muscle congestive heart failure).
SurgerySometimes cardiac catheterization reveals extensive coronary artery disease. In such cases, you will need to undergo coronary bypass surgery.
Standard coronary artery bypass grafting (CABG) is performed if many coronary arteries are narrowed or blocked. This is especially recommended when the left main coronary artery shows significant blockage. This is "open heart surgery," meaning that the chest wall is opened. When performing a bypass, heart surgeons use sections of the mammary artery from the chest, radial arteries from the arms, or veins from the legs to create detours around the blocked arteries. For this surgery, you will be connected to a bypass pump, which does the work of the heart during the operation. Although this sounds dangerous, this surgery is considered very safe and has a very low rate of complications.
Off-pump bypass surgery: Sometimes the surgeon can perform open heart surgery without using a bypass pump. The heart continues to beat during surgery. This type of surgery has even fewer complications than the standard procedure but is not always feasible.
Minimally invasive coronary bypass: If just the front or the right coronary artery needs bypass, the bypass may be performed via a small keyhole-type incision without a large incision in the chest. The internal mammary artery is used for the bypass.
Next Steps
Follow-upIf you have a heart attack, you will receive detailed instructions for your care after leaving the hospital. You should follow these instructions carefully. The following general guidelines apply to recovery from an uncomplicated heart attack.
You may return to work or prior activity levels after about 2 weeks, resume sexual activity in 7-10 days, drive a week after leaving the hospital, and continue commercial air travel after 2 weeks, if you are feeling fine and totally asymptomatic. Those with complicated heart attacks or who still have symptoms should wait at least 2-3 weeks after symptoms go away before driving.
After a heart attack, you will need close follow-up with your health care provider.
Coronary heart disease is a chronic (ongoing, long-term), progressive condition.
Changing your risk factors only slows its pace.
Angioplasty or bypass surgery only alleviates the symptoms and is not a cure. The disease may recur and progress.
Your health care provider will watch you carefully for the following developments:
Any new symptoms or signs of disease progression through clinical evaluation, physical examination, and periodic ECGs or stress tests
Silent ischemia by periodic treadmill or radionuclide stress tests or stress echocardiography
He or she will also manage the following aspects of your treatment and recovery:
Risk factor management by checking blood pressure and cholesterol levels periodically
Adjustment of medicines and management of their side effects
Prescription for an exercise program (cardiac rehabilitation)
PreventionHeart attack prevention depends on monitoring and modifying certain risk factors. These risk factors are interrelated. Each of us may have one or more risk factors. If we make moderate change in one area of life, we may reduce other risk factors at the same time.
Keep blood cholesterol levels in check.
Everyone adult should know what his or her cholesterol level is.
According to the National Cholesterol Education Program guidelines, if your cholesterol level is greater than 240 mg/dL or if the level of bad cholesterol (LDL) is above 130 mg/dL, aggressive measures should be taken to lower it.
If you can't lower your levels through diet alone, medications can help.
Lipid- and cholesterol-lowering drugs such as statins can reduce the rate of progression of coronary heart disease and also reduce repeat heart attacks. They work by lowering cholesterol and modifying the inner lining of your arteries.
Eat a well-balanced diet.
Avoid eating large amounts of fat and cholesterol in your diet because these can accelerate the progression of hardening and clogging of coronary arteries.
A well-balanced diet is good not only for those with high cholesterol but also for everyone. It helps to control cholesterol level as well as weight.
The American Heart Association recommends that the maximum number of calories from fat be less than 30% of total calories.
Limit the amount of fast food you eat.
Most fast food is very high in fat, even the salads and other so-called "healthy" foods.
This may not be convenient but may provide significant benefit in the long run.
Drink alcohol in moderation, if at all.
Although some research suggests that alcohol can help protect against heart disease, limit your intake to 1-2 drinks per day.
Larger amounts can increase blood pressure, cause heart rhythm disturbances, and damage the heart muscle or liver.
Stop smoking.
Quitting smoking is the single best lifestyle change you can make.
Passive smoking, smoking cigars, or chewing tobacco are also dangerous to health.
Quitting is difficult for most people. Ask your health care provider for advice and support.
Increase your physical activity.
Exercise helps to lower the blood pressure, increase the level of good cholesterol (HDL), and control excess weight.
Start slowly if you need to, but try to reach the goal of at least 30 minutes of endurance exercise 3-5 times a week. Such exercises include walking, swimming, biking, and aerobics.
Almost everyone can take part in some form of physical activity.
Before beginning an exercise program, talk to your health care provider.
Lose extra weight.
Being overweight puts extra strain on the heart and blood vessels.
A high-fiber, low-fat diet and regular exercise can help you lose weight and keep it off.
Many diets are promoted by people with self-interest. Some of these may be unsafe.
Get advice from your health care provider before starting any nontraditional weight loss program.
Avoid "diet pills" (such as Fen-Phen). Some of these have been found to cause heart valve disease or other dangerous conditions in some users.
"Natural" weight-loss products such as ephedrine can be very dangerous.